Abstract
The growth hormone (GH) is the main regulator of postnatal growth and metabolism in mammals. The action of GH on target cells depends on the growth hormone receptor (GHR). This is mediated through induced transcription of other genes. <em>GHR</em> gene is one of the candidate genes employed in selection strategy using DNA markers (marker assisted selection). This study was designed to identify the novel single nucleotide polymorphisms (SNPs) in exon 8 and intron 8 of <em>GHR</em> gene that may affect production traits in Bali cattle. A SNP was identified by the direct sequencing technique. Genotypes of the SNPs were identified using PCR-RFLP. The SNP was located in intron 8 of the <em>GHR</em> gene and was caused by an A/G transition. It was identified using the <em>HpyCH4III</em> restriction enzyme. Polymorphism of <em>GHR/HpyCH4III</em> has a significant influence on weaning weight and average daily gain, but not on birth weight of Bali cattle.