source: Indonesian Journal of Chemistry
Abstract
The objective of this research was to synthesize isoquino[2,1-c][1,3]benzodiazepine from papaverine alkaloid. Functional Group Interconversion (FGI) and Carbon -Nitrogen bond connection approach was investigated. Papaverine (1) was nitrated by HNO3 to compound (2) and followed by reduction with Sn and HCl to afford aminonorlaudanosine (3). Formation of cyclic benzodiazepine (4) was achieved by reaction of (3) with CS2. Products of reactions were confirmed by Nuclear Magnetic Resonances (n.m.r), Mass Spectrum, and Fourier Transform Infra Red (FTIR). Keywords: isoquino[2,1-c][1,3]benzodiazepine, papaverine
Concepts :
Analytical Chemistry and Chromatography
Synthesis and pharmacology of benzodiazepine derivatives
Chemical synthesis and alkaloids
article
cite 0
Year 2010
source Indonesian Journal of Chemistry