Abstract
Dermatitis atopik (DA) adalah kelainan kulit dengan gejala pruritus kronis. Etiopatogenesis penyakit ini kompleks dan multifactorial dengan gabungan aspek genetik, imunologi, dan lingkungan. Stres oksidatif sistemik maupun lokal diduga berperan penting dalam patogenesis DA. Pemberian antioksidan sistemik berupa vitamin A, C, D, D3, E, astaxanthin dan antioksidan topikal berupa vitamin B12, E, dan <em>superoxide dismutase</em> (SOD) dapat memperbaiki kondisi DA dengan bermakna.<br /><br />Atopic dermatitis (AD) is a skin disorder with chronic pruritic symptoms. Its etiopathogenesis is complex and multifactorial, with a combination of genetic, immunological and environmental aspects. Both systemic and local oxidative stress are thought to have an important role in the pathogenesis of AD. Systemic antioxidants in the form of vitamins A, C, D, D3, E, astaxanthin and topical antioxidants in the form of vitamins B12, E, and <em>superoxide dismutase</em> (SOD) give significant recovery of AD.
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