Abstract

Synthesis of calix [4]resorcinarene derivatives and their activity as an antioxidant has been carried out.The calix[4]resorcinarene was synthesized through a condensation reaction of resorcinol, valeraldehyde, and benzaldehyde using HCl as a catalyst with ethanol as a solvent (73 C, 24 h).Two synthesized products, C-butilcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene were successfully prepared with 44.70% and 43.5% yield, respectively.Their chemical structure was elucidated by Fourier Transform Infrared (FTIR) and Proton Nuclear Magnetic Resonance ( 1 H-NMR) analysis.The antioxidant activity assay of these compounds was evaluated through an in vitro assay of 2,2diphenyl-1-picrylhydrazyl (DPPH) radicals.The DPPH assay showed that the halfmaximal inhibitory concentration (IC 50 ) values of C-butylcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene were 6.28 ppm and 18.76 ppm, respectively.This finding demonstrates that both C-butylcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene have very strong antioxidant properties.

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