Abstract

Background: Lead intoxication triggers testicular toxicity via oxidative stress. Aim: leaf extract (MOLE) in enhancing the semen quality of rats exposed to lead acetate. Methods: Twenty-five healthy rats were randomly and equally divided into five groups. Group C served as the negative control, whereas group C+ was exposed to lead acetate at 50-mg/kg body weight (BW)/day without MOLE. The T1, T2, and T3 groups were exposed to lead acetate at 50-mg/kg BW and concurrently received MOLE at doses of 200-, 316-, and 500-mg/kg BW/day, respectively, for 20 days. On the 21st day, all rats were euthanized for blood collection and testicle harvesting. Results: < 0.05) compared with control group C-. Conclusion: MOLE effectively restores sperm quality in lead acetate-induced rats.

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