Abstract
Background: Chronic systemic disease known as diabetes mellitus (DM) is defined by elevated blood glucose levels and problems with fat, carbohydrate, and protein metabolism. In Indonesia, the cinnamon species found include Cinnamomum burmannii, which also has hypoglycemic activity. The primary antioxidant chemicals found in Cinnamomum burmanii bark extract are polyphenols, which include tannins and flavonoids. Aim: The antidiabetic activity of cinnamon essential oil (Cinnamomum burmannii) against streptozotocin (STZ) was examined in this study. Methods: STZ (45 mg/kgBW) was administered intraperitoneally as a single dose. Twenty male rats were employed in this investigation. The rats were divided into five groups: treatment 1 (P1) was administered with streptozotocin and provided with 100 mg/kgBW; treatment 2 (P2) was administered with streptozotocin and provided with 200 mg/kgBW; and treatment 3 (P3) was administered with streptozotocin and provided with 400 mg/kgBW. The negative control group (K-) was not treated with streptozotocin and was treated with 1% Tween 80. For 14 days, the medication was administered daily. Results: The essential oil of cinnamon may lessen glomerulosclerosis, tubular necrosis, tubular degeneration, and glomerular necrosis. The kidney P3 treatment (400 mg/kgBW) produced negligible effects. Conclusion: It is possible to create cinnamon essential oil as an herbal antidiabetic medication by lowering the degree of kidney cell damage.