Abstract

The synthesis of sulfonated hydroxyxanthones (4a and 4b) was streamlined into a single sequence to reduce steps and enhance efficiency. This study also investigated the molecular docking of these synthesized compounds as potential anti-TB agents. Using AutoDock Vina, the docking results indicated that compounds 4a and 4b exhibit promising anti-TB activity by effectively binding to the DHPS enzyme. This enzyme, crucial for Mycobacterium tuberculosis growth, was specifically targeted in the study, underscoring the compounds' potential to inhibit DHPS and their suitability as anti-TB drugs.

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